kératinisation

Bone changes including premature epiphyseal closure, hyperostosis, and calcification of tendons and ligaments have occurred after several years of administration at very high doses for treating disorders of keratinisation.
Des altérations squelettiques telles que soudure prématurée des cartilages de conjugaison, hyperostoses et calcifications tendineuses ou ligamentaires sont survenues après administration de très fortes doses d'isotrétinoïne durant plusieurs années en traitement de troubles de kératinisation.
Bone changes including premature epiphyseal closure, hyperostosis, and calcification of tendons and ligaments have occurred after several years of administration at very high doses for treating disorders of keratinisation.
La sécheresse oculaire peut être prévenue par l'application d'une pommade ophtalmique lubrifiante ou de larmes artificielles.
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