désamination

L’ azacitidine est métabolisée par hydrolyse spontanée et par désamination par la cytidine désaminase.
Metabolism of azacitidine is by spontaneous hydrolysis and by deamination mediated by cytidine deaminase.
La substitution unique du chlore à l'hydrogène en position 2 distingue la cladribine de son équivalent naturel, la 2'-désoxyadénosine, et rend la molécule résistante à la désamination par l'adénosine désaminase.
The single substitution of chlorine for hydrogen at position 2 distinguishes cladribine from its natural counterpart 2'-deoxyadenosine and renders the molecule resistant to deamination by adenosine deaminase.
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